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EnglishCats immunized with cells infected with a primary isolate of feline immunodeficiency virus (FIV) and fixed with paraformaldehyde were challenged with cell-free or cell-associated homologous virus obtained ex vivo. Complete protection was observed in animals challenged with cell-free virus-4 months after completion of vaccination (p.v.) or with cell-associated virus 12 months p.v. In contrast, no protection was observed in cats challenged with cell-free virus 12 or 28 months p.v or with cell-associated virus 37.5 months p.v. Prior to the 28- and 37.5-month challenges, the animals had received a booster dose of vaccine that had elicited a robust anamnestic immune response. These results show that vaccine-induced protection against ex vivo FIV is achievable but is relatively short-lived and can be difficult to boost.
| Autori interni: | ||
| Autori: | Matteucci, D; Pistello, Mauro; Mazzetti, P; Giannecchini, S; Delmauro, D; Lonetti, I; Zaccaro, L; Pollera, C; Specter, S; Bendinelli, M. | |
| Titolo: | Studies of AIDS vaccination using an ex vivo feline immunodeficiency virus model: Protection conferred by a fixed-cell vaccine against cell-free and cell-associated challenge differs in duration and is not easily boosted | |
| Anno del prodotto: | 1997 | |
| Abstract: | Cats immunized with cells infected with a primary isolate of feline immunodeficiency virus (FIV) and fixed with paraformaldehyde were challenged with cell-free or cell-associated homologous virus obtained ex vivo. Complete protection was observed in animals challenged with cell-free virus-4 months after completion of vaccination (p.v.) or with cell-associated virus 12 months p.v. In contrast, no protection was observed in cats challenged with cell-free virus 12 or 28 months p.v or with cell-associated virus 37.5 months p.v. Prior to the 28- and 37.5-month challenges, the animals had received a booster dose of vaccine that had elicited a robust anamnestic immune response. These results show that vaccine-induced protection against ex vivo FIV is achievable but is relatively short-lived and can be difficult to boost. | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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