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EnglishNeutralizing antibodies are necessary and sufficient for protection against infection with vesicular stomatitis virus(VSV). The in vitro neutralization capacities and in vivo protective capacities of a panel of immunoglobulin G monoclonal antibodies to the glycoprotein of VSV were evaluated. In vitro, neutralizing activity correlated with avidity and with neutralization rate constant, a measure of on-rate. However, in vivo, protection was independent of immunoglobulin subclass, avidity, neutralization rate constant, and in vitro neutralizing activity; above a minimal avidity threshold, protection depended simply on a minimum serum concentration. These two biologically defined thresholds of antibody specificity offer hope for the development of adoptive therapy with neutralizing antibodies.
| Autori interni: | |
| Autori: | Bachmann MF; Kalinke U; Althage A; Freer G; Burkhart C; Roost HP; Aguet M; Hengartner H; Zinkernagel RM |
| Titolo: | The role of antibody concentration and avidity in antiviral protection |
| Anno del prodotto: | 1997 |
| Digital Object Identifier (DOI): | 10.1126/science.276.5321.2024 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/55435
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