Two patients with coexistent Down's syndrome and gout are described. Although increased serum urate levels are frequently reported in Down's syndrome, only a few such patients have been described with concomitant gout. In our patients no significant alterations of the purine salvage pathway were found, and the turnover parameters of uric acid, determined by means of a 14C-labeled uric acid study, were consistent with the metabolic findings observed in normoexcretor gouty patients.

URIC-ACID METABOLISM IN 2 PATIENTS WITH COEXISTENT DOWNS-SYNDROME AND GOUT

CIOMPI, MARIA LAURA;MAZZONI, MARIA ROSA;MARIANI, GIULIANO
1984

Abstract

Two patients with coexistent Down's syndrome and gout are described. Although increased serum urate levels are frequently reported in Down's syndrome, only a few such patients have been described with concomitant gout. In our patients no significant alterations of the purine salvage pathway were found, and the turnover parameters of uric acid, determined by means of a 14C-labeled uric acid study, were consistent with the metabolic findings observed in normoexcretor gouty patients.
Ciompi, MARIA LAURA; Bazzichi, L; Bertolucci, D; Mazzoni, MARIA ROSA; Barbieri, P; Mencacci, S; Macchia, D; Mariani, Giuliano
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/5575
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