The effect of the antidiabetic agent vanadyl sulphate (VOSO4) on the endocrine pancreas function of normal rats was studied using the isolated pancreas preparation. A short-term (8 days) i.p. treatment (15 mg/kg per day) resulted in attenuation of high glucose-stimulated insulin release, at day 9 but also at days 19, i.e., after full recovery of appetite and weight, while blood and pancreas vanadium concentrations were still elevated. Six months of oral VOSO4 treatment (0.75 mg/ml in drinking water) resulted in elevated vanadium concentrations while glucose-stimulated insulin release was attenuated as compared to pair-fed animals. Conversely, when directly perfused in pancreas, VOSO4 potentiated glucose-stimulated insulin release. These apparently opposite effects may be related to the ability of VOSO4 to exert both peripheral insulinomimetic effects - leading to chronic reduction in insulin demand -, and a direct pancreatic insulinotropic activity.
|Autori:||Cadene A; Gross R; Poucheret P; Mongold JJ; Masiello P; Roye M; Ribes G; Serrano JJ; Cros G|
|Titolo:||Vanadyl sulphate differently influences insulin response to glucose in isolated pancreas of normal rats after in vivo or in vitro exposure|
|Anno del prodotto:||1996|
|Digital Object Identifier (DOI):||10.1016/S0014-2999(96)00768-6|
|Appare nelle tipologie:||1.1 Articolo in rivista|