Both enantiomers of cis-beta-ethyl, beta-n-propyl, beta-n-butyl, and beta-n-hexyl substituted styrene oxides undergo microsomal epoxide hydrolase catalysed hydration at the (S) carbon to give the corresponding (R,R) three diols in a > 90% e.e. A complete kinetic resolution of the racemic epoxide is also obtained with the beta-ethyl substituted substrate, but not with its higher homologues.
Autori interni: | |
Autori: | Bellucci G; Chiappe C; Cordoni A |
Titolo: | Enantioconvergent transformation of racemic cis-beta-alkyl substituted styrene oxides to (R,R) threo diels by microsomal epoxide hydrolase catalysed hydrolysis |
Anno del prodotto: | 1996 |
Digital Object Identifier (DOI): | 10.1016/0957-4166(95)00436-X |
Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.