Enantioconvergent transformation of racemic cis-beta-alkyl substituted styrene oxides to (R,R) threo diels by microsomal epoxide hydrolase catalysed hydrolysis

Bellucci, G; Chiappe, C; Cordoni, A

doi:10.1016/0957-4166(95)00436-X

Both enantiomers of cis-beta-ethyl, beta-n-propyl, beta-n-butyl, and beta-n-hexyl substituted styrene oxides undergo microsomal epoxide hydrolase catalysed hydration at the (S) carbon to give the corresponding (R,R) three diols in a > 90% e.e. A complete kinetic resolution of the racemic epoxide is also obtained with the beta-ethyl substituted substrate, but not with its higher homologues.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/55945

Autori interni:	CHIAPPE, CINZIA
Autori:	Bellucci G; Chiappe C; Cordoni A
Titolo:	Enantioconvergent transformation of racemic cis-beta-alkyl substituted styrene oxides to (R,R) threo diels by microsomal epoxide hydrolase catalysed hydrolysis
Anno del prodotto:	1996
Digital Object Identifier (DOI):	10.1016/0957-4166(95)00436-X
Appare nelle tipologie:	1.1 Articolo in rivista

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