Phytochemical investigation of Sideritis pullulans aerial part and root extracts allowed to isolate six ent-kaurane diterpenes, two phenylpropanoids, and one coumarin, identified as 1α,3α,7β,18-tetrahydroxy-ent- kaur-16-ene (sideripullol A) (1), 3α,11α,18-trihydroxy-ent-kaur-16- ene (sideripullol B) (2), 3α,7β,18-trihydroxy-17-nor-ent-kauran-16- one (sideritone A) (3), 3α,7β-dihydroxy-18-acetyloxy-17-nor-ent- kauran-16-one (sideritone B) (4), 3α,7β,16α,17-tetrahydroxy-18- acetyloxy-ent-kaurane (sideripullol C) (5), 7β,16α,17,18- tetrahydroxy-ent-kaurane (sideripullol D) (6), β-(3-methoxy-4- hydroxyphenyl)-ethyl-O-α-l-arabinopiranosyl-(1 → 2)-α-l- rhamnopyranosyl-(1 → 3)-6-O-t-feruloyl-β-d-glucopyranoside (sideritiside A) (7), β-(3,4-dihydroxyphenyl)-ethyl-O-α-l- arabinopiranosyl-(1 → 2)-α-l-rhamnopyranosyl-(1 → 3)-6-O-t-feruloyl-β-d-glucopyranoside (sideritiside B) (8), and 7-demethyl-8-methoxycoumarsabin (9), respectively. Twenty known compounds, including phenolics, flavonol glycosides, iridoids, diterpenes, sesquiterpenes, lignans, coumarins, and phenylpropanoids were also isolated and characterized. All diterpenes were evaluated for their cytotoxic activity.

Diterpenes and phenolic compounds from Sideritis pullulans

FAIELLA, LAURA;BRACA, ALESSANDRA
2014

Abstract

Phytochemical investigation of Sideritis pullulans aerial part and root extracts allowed to isolate six ent-kaurane diterpenes, two phenylpropanoids, and one coumarin, identified as 1α,3α,7β,18-tetrahydroxy-ent- kaur-16-ene (sideripullol A) (1), 3α,11α,18-trihydroxy-ent-kaur-16- ene (sideripullol B) (2), 3α,7β,18-trihydroxy-17-nor-ent-kauran-16- one (sideritone A) (3), 3α,7β-dihydroxy-18-acetyloxy-17-nor-ent- kauran-16-one (sideritone B) (4), 3α,7β,16α,17-tetrahydroxy-18- acetyloxy-ent-kaurane (sideripullol C) (5), 7β,16α,17,18- tetrahydroxy-ent-kaurane (sideripullol D) (6), β-(3-methoxy-4- hydroxyphenyl)-ethyl-O-α-l-arabinopiranosyl-(1 → 2)-α-l- rhamnopyranosyl-(1 → 3)-6-O-t-feruloyl-β-d-glucopyranoside (sideritiside A) (7), β-(3,4-dihydroxyphenyl)-ethyl-O-α-l- arabinopiranosyl-(1 → 2)-α-l-rhamnopyranosyl-(1 → 3)-6-O-t-feruloyl-β-d-glucopyranoside (sideritiside B) (8), and 7-demethyl-8-methoxycoumarsabin (9), respectively. Twenty known compounds, including phenolics, flavonol glycosides, iridoids, diterpenes, sesquiterpenes, lignans, coumarins, and phenylpropanoids were also isolated and characterized. All diterpenes were evaluated for their cytotoxic activity.
Faiella, Laura; F., Dal Piaz; A., Bader; Braca, Alessandra
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/565271
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