Phytochemical investigation of Sideritis pullulans aerial part and root extracts allowed to isolate six ent-kaurane diterpenes, two phenylpropanoids, and one coumarin, identified as 1α,3α,7β,18-tetrahydroxy-ent- kaur-16-ene (sideripullol A) (1), 3α,11α,18-trihydroxy-ent-kaur-16- ene (sideripullol B) (2), 3α,7β,18-trihydroxy-17-nor-ent-kauran-16- one (sideritone A) (3), 3α,7β-dihydroxy-18-acetyloxy-17-nor-ent- kauran-16-one (sideritone B) (4), 3α,7β,16α,17-tetrahydroxy-18- acetyloxy-ent-kaurane (sideripullol C) (5), 7β,16α,17,18- tetrahydroxy-ent-kaurane (sideripullol D) (6), β-(3-methoxy-4- hydroxyphenyl)-ethyl-O-α-l-arabinopiranosyl-(1 → 2)-α-l- rhamnopyranosyl-(1 → 3)-6-O-t-feruloyl-β-d-glucopyranoside (sideritiside A) (7), β-(3,4-dihydroxyphenyl)-ethyl-O-α-l- arabinopiranosyl-(1 → 2)-α-l-rhamnopyranosyl-(1 → 3)-6-O-t-feruloyl-β-d-glucopyranoside (sideritiside B) (8), and 7-demethyl-8-methoxycoumarsabin (9), respectively. Twenty known compounds, including phenolics, flavonol glycosides, iridoids, diterpenes, sesquiterpenes, lignans, coumarins, and phenylpropanoids were also isolated and characterized. All diterpenes were evaluated for their cytotoxic activity.
Diterpenes and phenolic compounds from Sideritis pullulans
FAIELLA, LAURA;BRACA, ALESSANDRA
2014-01-01
Abstract
Phytochemical investigation of Sideritis pullulans aerial part and root extracts allowed to isolate six ent-kaurane diterpenes, two phenylpropanoids, and one coumarin, identified as 1α,3α,7β,18-tetrahydroxy-ent- kaur-16-ene (sideripullol A) (1), 3α,11α,18-trihydroxy-ent-kaur-16- ene (sideripullol B) (2), 3α,7β,18-trihydroxy-17-nor-ent-kauran-16- one (sideritone A) (3), 3α,7β-dihydroxy-18-acetyloxy-17-nor-ent- kauran-16-one (sideritone B) (4), 3α,7β,16α,17-tetrahydroxy-18- acetyloxy-ent-kaurane (sideripullol C) (5), 7β,16α,17,18- tetrahydroxy-ent-kaurane (sideripullol D) (6), β-(3-methoxy-4- hydroxyphenyl)-ethyl-O-α-l-arabinopiranosyl-(1 → 2)-α-l- rhamnopyranosyl-(1 → 3)-6-O-t-feruloyl-β-d-glucopyranoside (sideritiside A) (7), β-(3,4-dihydroxyphenyl)-ethyl-O-α-l- arabinopiranosyl-(1 → 2)-α-l-rhamnopyranosyl-(1 → 3)-6-O-t-feruloyl-β-d-glucopyranoside (sideritiside B) (8), and 7-demethyl-8-methoxycoumarsabin (9), respectively. Twenty known compounds, including phenolics, flavonol glycosides, iridoids, diterpenes, sesquiterpenes, lignans, coumarins, and phenylpropanoids were also isolated and characterized. All diterpenes were evaluated for their cytotoxic activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.