The changes of brain tryptophan and 5-HT levels have been explored in the diabetic rat during the first hour after an intraperitoneal load of tryptophan. The obtained data confirm that diabetes decreases the basal levels of tryptophan but not those of 5-HT. Also, it has been shown that diabetes remarkably depresses the rate of the aminoacid accumulation and almost completely inhibits the rise of 5-HT after the tryptophan load.

Effects of a tryptophan load on brain levels of serotonin in normal and diabetic rats

MASIELLO, PELLEGRINO;BERGAMINI, ETTORE
1981

Abstract

The changes of brain tryptophan and 5-HT levels have been explored in the diabetic rat during the first hour after an intraperitoneal load of tryptophan. The obtained data confirm that diabetes decreases the basal levels of tryptophan but not those of 5-HT. Also, it has been shown that diabetes remarkably depresses the rate of the aminoacid accumulation and almost completely inhibits the rise of 5-HT after the tryptophan load.
Masiello, Pellegrino; Bufardeci, F; Bergamini, Ettore
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/5661
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