We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

RIZZATO, COSMERI;CAMPA, DANIELE;LANDI, STEFANO;
2014

Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
Wolpin, Bm; Rizzato, Cosmeri; Kraft, P; Kooperberg, C; Petersen, Gm; Wang, Z; Arslan, Aa; Beane Freeman, L; Bracci, Pm; Buring, J; Canzian, F; Duell, Ej; Gallinger, S; Giles, Gg; Goodman, Ge; Goodman, Pj; Jacobs, Ej; Kamineni, A; Klein, Ap; Kolonel, Ln; Kulke, Mh; Li, D; Malats, N; Olson, Sh; Risch, Ha; Sesso, Hd; Visvanathan, K; White, E; Zheng, W; Abnet, Cc; Albanes, D; Andreotti, G; Austin, Ma; Barfield, R; Basso, D; Berndt, Si; Boutron Ruault, Mc; Brotzman, M; Buechler, Mw; Bueno de Mesquita, Hb; Bugert, P; Burdette, L; Campa, Daniele; Caporaso, Ne; Capurso, G; Chung, C; Cotterchio, M; Costello, E; Elena, J; Funel, N; Gaziano, Jm; Giese, Na; Giovannucci, El; Goggins, M; Gorman, Mj; Gross, M; Haiman, Ca; Hassan, M; Helzlsouer, Kj; Henderson, Be; Holly, Ea; Hu, N; Hunter, Dj; Innocenti, F; Jenab, M; Kaaks, R; Key, Tj; Khaw, Kt; Klein, Ea; Kogevinas, M; Krogh, V; Kupcinskas, J; Kurtz, Rc; Lacroix, A; Landi, Mt; Landi, Stefano; Le Marchand, L; Mambrini, A; Mannisto, S; Milne, Rl; Nakamura, Y; Oberg, Al; Owzar, K; Patel, Av; Peeters, Ph; Peters, U; Pezzilli, R; Piepoli, A; Porta, M; Real, Fx; Riboli, E; Rothman, N; Scarpa, A; Shu, Xo; Silverman, Dt; Soucek, P; Sund, M; Talar Wojnarowska, R; Taylor, Pr; Theodoropoulos, Ge; Thornquist, M; Tjonneland, A; Tobias, Gs; Trichopoulos, D; Vodicka, P; Wactawski Wende, J; Wentzensen, N; Wu, C; Yu, H; Yu, K; Zeleniuch Jacquotte, A; Hoover, R; Hartge, P; Fuchs, C; Chanock, Sj; Stolzenberg Solomon, Rs; Amundadottir, Lt
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/599669
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