The effect of tuberculin purified protein derivative (PPD) on the development of plaque-forming cells (PFC) against bromelain-treated syngeneic mouse red blood cells (Br-MRBC) was studied in peritoneal cell cultures. The finding that PPD enhances the development of PFC to Br-MRBC, even under conditions where cell division is blocked by mitomycin C treatment, suggests that cell proliferation does not represent a necessary prerequisite for differentiation of precursor cells into autoantibody-forming cells.

ENHANCEMENT OF THE SPONTANEOUS DEVELOPMENT OF AUTOREACTIVE-B CELLS BY PPD IN MOUSE PERITONEAL CELL-CULTURES

CAMPA, MARIO;GARZELLI, CARLO;
1983

Abstract

The effect of tuberculin purified protein derivative (PPD) on the development of plaque-forming cells (PFC) against bromelain-treated syngeneic mouse red blood cells (Br-MRBC) was studied in peritoneal cell cultures. The finding that PPD enhances the development of PFC to Br-MRBC, even under conditions where cell division is blocked by mitomycin C treatment, suggests that cell proliferation does not represent a necessary prerequisite for differentiation of precursor cells into autoantibody-forming cells.
Campa, Mario; Garzelli, Carlo; Colizzi, V; Benedettini, G; Delibero, G; Falcone, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/6599
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