The effect of tuberculin purified protein derivative (PPD) on the development of plaque-forming cells (PFC) against bromelain-treated syngeneic mouse red blood cells (Br-MRBC) was studied in peritoneal cell cultures. The finding that PPD enhances the development of PFC to Br-MRBC, even under conditions where cell division is blocked by mitomycin C treatment, suggests that cell proliferation does not represent a necessary prerequisite for differentiation of precursor cells into autoantibody-forming cells.
|Autori:||CAMPA M; GARZELLI C; COLIZZI V; BENEDETTINI G; DELIBERO G; FALCONE G|
|Titolo:||ENHANCEMENT OF THE SPONTANEOUS DEVELOPMENT OF AUTOREACTIVE-B CELLS BY PPD IN MOUSE PERITONEAL CELL-CULTURES|
|Anno del prodotto:||1983|
|Appare nelle tipologie:||1.1 Articolo in rivista|