Coupling reactions between 2- or 3-thienylmagnesium bromide and dibromothiophenes in the presence of catalytic amts. of PdCl2[1,1'-bis(diphenylphosphino)ferrocene] gave 48-85% of three isomers of terthiophene as well as several bromobithiophenes.  Thiophene esters I (R = H, 2-thienyl, 3-thienyl) were prepd. by Pd-catalyzed ethoxycarbonylation of bromothiophenes II under mild conditions.  A short synthesis of naturally occurring (propynyl)bithienylcarboxylic acid III, from 2-thienylmagnesium bromide using Pd-catalyzed reactions, is reported.

Palladium-catalyzed syntheses of bi- and terthiophenes

CARPITA, ADRIANO;ROSSI, RENZO
1985

Abstract

Coupling reactions between 2- or 3-thienylmagnesium bromide and dibromothiophenes in the presence of catalytic amts. of PdCl2[1,1'-bis(diphenylphosphino)ferrocene] gave 48-85% of three isomers of terthiophene as well as several bromobithiophenes.  Thiophene esters I (R = H, 2-thienyl, 3-thienyl) were prepd. by Pd-catalyzed ethoxycarbonylation of bromothiophenes II under mild conditions.  A short synthesis of naturally occurring (propynyl)bithienylcarboxylic acid III, from 2-thienylmagnesium bromide using Pd-catalyzed reactions, is reported.
Carpita, Adriano; Rossi, Renzo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/6624
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