A series of neutral complexes of platinum(II) of general formula [PtCl2L(PPh3)] [L = Et2NC(Me)NH, SOMe2, CO, Et2NH, (HOCH2CH2)2NH, Bz2NH, N-morpholine] was prepared starting from suitable precursors. The syntheses and spectroscopic characterizations of the two new complexes trans-[PtCl2(N-morpholine)(PPh3)] and cis-[PtCl2(SOMe2)(PPh3)] are described as well as their X-ray structures. The antiproliferative activity of all the available compounds was tested in vitro against HeLa, H460 and A549 human tumor cell lines. A brief discussion regarding the structure–activity correlation is presented.

Antiproliferative activity of Platinum(II) complexes containing triphenylphosphine: correlation between structure and biological activity

BELLI, DANIELA;LABELLA, LUCA;MARCHETTI, FABIO;SAMARITANI, SIMONA
2015

Abstract

A series of neutral complexes of platinum(II) of general formula [PtCl2L(PPh3)] [L = Et2NC(Me)NH, SOMe2, CO, Et2NH, (HOCH2CH2)2NH, Bz2NH, N-morpholine] was prepared starting from suitable precursors. The syntheses and spectroscopic characterizations of the two new complexes trans-[PtCl2(N-morpholine)(PPh3)] and cis-[PtCl2(SOMe2)(PPh3)] are described as well as their X-ray structures. The antiproliferative activity of all the available compounds was tested in vitro against HeLa, H460 and A549 human tumor cell lines. A brief discussion regarding the structure–activity correlation is presented.
Belli, Daniela; Dalla Via, Lisa; García Argáez, Aída Nelly; Labella, Luca; Marchetti, Fabio; Samaritani, Simona
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/674863
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