EnglishA series of neutral complexes of platinum(II) of general formula [PtCl2L(PPh3)] [L = Et2NC(Me)NH, SOMe2, CO, Et2NH, (HOCH2CH2)2NH, Bz2NH, N-morpholine] was prepared starting from suitable precursors. The syntheses and spectroscopic characterizations of the two new complexes trans-[PtCl2(N-morpholine)(PPh3)] and cis-[PtCl2(SOMe2)(PPh3)] are described as well as their X-ray structures. The antiproliferative activity of all the available compounds was tested in vitro against HeLa, H460 and A549 human tumor cell lines. A brief discussion regarding the structure–activity correlation is presented.
| Autori: | |
| Autori: | Belli Dell’Amico, Daniela; Dalla Via, Lisa; García-Argáez, Aída Nelly; Labella, Luca; Marchetti, Fabio; Samaritani, Simona |
| Titolo: | Antiproliferative activity of Platinum(II) complexes containing triphenylphosphine: correlation between structure and biological activity |
| Anno del prodotto: | 2015 |
| Digital Object Identifier (DOI): | 10.1016/j.poly.2014.10.00 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Polyhedron Pt 2015.pdf | Editoriale | NON PUBBLICO - Accesso privato/ristretto | Utenti riconosciuti Richiedi una copia |
Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11568/674863
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