A series of neutral complexes of platinum(II) of general formula [PtCl2L(PPh3)] [L = Et2NC(Me)NH, SOMe2, CO, Et2NH, (HOCH2CH2)2NH, Bz2NH, N-morpholine] was prepared starting from suitable precursors. The syntheses and spectroscopic characterizations of the two new complexes trans-[PtCl2(N-morpholine)(PPh3)] and cis-[PtCl2(SOMe2)(PPh3)] are described as well as their X-ray structures. The antiproliferative activity of all the available compounds was tested in vitro against HeLa, H460 and A549 human tumor cell lines. A brief discussion regarding the structure–activity correlation is presented.
|Autori interni:||BELLI, DANIELA|
|Autori:||Belli Dell’Amico, Daniela; Dalla Via, Lisa; García-Argáez, Aída Nelly; Labella, Luca; Marchetti, Fabio; Samaritani, Simona|
|Titolo:||Antiproliferative activity of Platinum(II) complexes containing triphenylphosphine: correlation between structure and biological activity|
|Anno del prodotto:||2015|
|Digital Object Identifier (DOI):||10.1016/j.poly.2014.10.00|
|Appare nelle tipologie:||1.1 Articolo in rivista|