Trans, trans-muconic acid (tt-MA) is one of the most important metabolites of benzene, a pollutant ubiquitously distributed in ambient air and classified in 1982 as a group I carcinogen. For its sensitivity and specificity, tt-MA excreted in urine is considered a good biological marker of benzene exposure. In this study, seminal tt-MA levels in occupationally nonexposed subjects (n = 32) have been determined. The seminal fluid of normozoospermic subjects contained an average tt-MA concentration (170 +/- 100 ng ml(-1)) significantly lower than that of teratozoospermic (310 +/- 180 ng ml(-1); P <0.01), oligozoospermic (400 +/- 180 ng ml(-1); P <0.001), and oligoasthenozoospermic. (430 +/- 230 ng ml(-1); P <0.01) subjects. A negative correlation existed between tt-MA levels and sperm concentration (r = -0.62; P <0.001), percentage of normal spermatozoa (r = -0.41; P <0.05), and percentage of vital spermatozoa (r = -0.89; P <0.001). Average tt-MA levels detected in seminal plasma were higher in smokers (350 +/- 160 ng ml(-1)) than in nonsmokers (280 +/- 210 ng ml(-1)) These results show that seminal plasma tt-MA content could be an important biological indicator for evaluating the negative effects of benzene on spermatogenesis.

Assessment of trans, trans-muconic acid in human seminal plasma

DUCCI, MICHELE;ROSSI, PAOLO;GAZZANO, ANGELO;MARTELLI, FRANCO;
2001

Abstract

Trans, trans-muconic acid (tt-MA) is one of the most important metabolites of benzene, a pollutant ubiquitously distributed in ambient air and classified in 1982 as a group I carcinogen. For its sensitivity and specificity, tt-MA excreted in urine is considered a good biological marker of benzene exposure. In this study, seminal tt-MA levels in occupationally nonexposed subjects (n = 32) have been determined. The seminal fluid of normozoospermic subjects contained an average tt-MA concentration (170 +/- 100 ng ml(-1)) significantly lower than that of teratozoospermic (310 +/- 180 ng ml(-1); P <0.01), oligozoospermic (400 +/- 180 ng ml(-1); P <0.001), and oligoasthenozoospermic. (430 +/- 230 ng ml(-1); P <0.01) subjects. A negative correlation existed between tt-MA levels and sperm concentration (r = -0.62; P <0.001), percentage of normal spermatozoa (r = -0.41; P <0.05), and percentage of vital spermatozoa (r = -0.89; P <0.001). Average tt-MA levels detected in seminal plasma were higher in smokers (350 +/- 160 ng ml(-1)) than in nonsmokers (280 +/- 210 ng ml(-1)) These results show that seminal plasma tt-MA content could be an important biological indicator for evaluating the negative effects of benzene on spermatogenesis.
Ducci, Michele; Tedeschi, D; Rossi, Paolo; Gazzano, Angelo; Villani, C; Voliani, S; Bertozzi, Ma; Martelli, Franco; Menchini Fabris, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/67829
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