The "priming effect" is studied to ascertain whether a regulatory system of local immune response exists and, if it does, what its function is. Bursectomized, bursa-ligated and silica-treated chicks were used, together with control birds (silica selectively damages the follicle associated epithelial -FAE- cells). Agglutinins and direct plaque forming cells (PFC)/spleen were checked. The results confirm that contact between the antigen and the bursal tissue acts as a primary stimulus for immune response and that extrabursal lymphoid sites are unable to act in the same way as the bursa of Fabricius. It seems quite probable, then, that a regulatory system of local immune response exists.
|Autori interni:||DOLFI, AMELIO|
|Autori:||LUPETTI M; DOLFI A; MALATESTA T; MICHELUCCI S|
|Titolo:||A CONTRIBUTION TO THE STUDY OF THE REGULATORY SYSTEM OF LOCAL IMMUNE-RESPONSE IN GALLUS DOMESTICUS|
|Anno del prodotto:||1984|
|Digital Object Identifier (DOI):||10.1016/0145-305X(84)90098-3|
|Appare nelle tipologie:||1.1 Articolo in rivista|