EnglishMitochondrial glycerophosphate-acetyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats, A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10(-5) M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity.
| Autori: | |
| Autori: | Tessari P; Meneghel A; Avogaro A; Duner E; Del Prato S; Tuzzato M; Tiengo A |
| Titolo: | Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect. |
| Anno del prodotto: | 1981 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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http://hdl.handle.net/11568/6897
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