Mitochondrial glycerophosphate-acetyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats, A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10(-5) M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity.
|Autori:||Tessari P; Meneghel A; Avogaro A; Duner E; Del Prato S; Tuzzato M; Tiengo A|
|Titolo:||Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect.|
|Anno del prodotto:||1981|
|Appare nelle tipologie:||1.1 Articolo in rivista|