Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect.

Tessari, P; Meneghel, A; Avogaro, A; Duner, E; Del Prato, S; Tuzzato, M; Tiengo, A

Mitochondrial glycerophosphate-acetyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats, A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10(-5) M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/6897

Autori interni:	DEL PRATO, STEFANO
Autori:	Tessari P; Meneghel A; Avogaro A; Duner E; Del Prato S; Tuzzato M; Tiengo A
Titolo:	Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect.
Anno del prodotto:	1981
Appare nelle tipologie:	1.1 Articolo in rivista

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