Mitochondrial glycerophosphate-acetyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats, A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10(-5) M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity.
Autori interni: | |
Autori: | Tessari P; Meneghel A; Avogaro A; Duner E; Del Prato S; Tuzzato M; Tiengo A |
Titolo: | Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect. |
Anno del prodotto: | 1981 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.