Previous studies have shown that resveratrol, a phytoalexin present with other phenols in grapes and wine, inhibits the release of inflammatory cytokines from human isolated monocytes. The present study demonstrates that the presence of resveratrol inhibits the release of interleukin (IL)-1-alpha and IL-6 induced by lipopolysaccharide, These results confirm the modulatory effects of resveratrol on the nuclear factor-kappaB and activator protein 1 signal transduction systems, thus explaining the possible mechanisms of antiinflammatory antiatherosclerotic and cardioprotective activity of resveratrol.
|Autori:||Bertelli AAE; Migliori M; Giovannini L; Filippi C; Panichi V; Bertelli A; Falchi M|
|Titolo:||Resveratrol prevents interleukin release from isolated monocytes|
|Anno del prodotto:||2002|
|Appare nelle tipologie:||1.1 Articolo in rivista|