Recent data indicate that overexpression of the enzyme Cu,Zn superoxide dismutase (SOD1) in mice confers neuroprotection against various dopamine neurotoxins like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), methamphetamine, 6-hydroxydopamine and methylenedioxymethamphetamine. In the present study we investigated whether a mutant form of SOD1 (G93A), occurring in humans affected by amyotrophic lateral sclerosis, leads to a differential vulnerability of nigrostriatal dopaminergic neurons to the chronic dopamine depletion induced by the selective neurotoxin MPTP. Our results indicate that overexpression of both wild-type and human mutant SOD1 induces comparable neuroprotective effects against striatal dopaminergic depletion. q 2002 Elsevier Science Ireland Ltd. All rights reserved.
|Autori:||FORNAI F; CARRI MT; FERRI A; PAOLUCCI E; PRISCO S; BERNARDI G; ROTILIO G; MERCURI NB|
|Titolo:||Resistance to striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice expressing human mutant Cu,Zn superoxide dismutase.|
|Anno del prodotto:||2002|
|Digital Object Identifier (DOI):||10.1016/S0304-3940(02)00252-5|
|Appare nelle tipologie:||1.1 Articolo in rivista|