Parkinson disease (PD) is a complex neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons. We used an in vitro rotenone-induced PD mouse model to verify the neuroprotective effects of C3, an exoenzyme produced by Clostridium botulinum that inactivates RhoA by ADP-ribosylation. Our data indicate that the inhibition of RhoA by C3 is able to partially rescue the rotenone induced damage by probably preventing microtubules depolymerization.
RhoA inhibition by C3 prevents dopaminergic neuronal degeneration in rotenone induced neurotoxicity
MATTII, LETIZIA;SABBATINI, ANTONIETTA RAFFAELLA MARIA;IPPOLITO, CHIARA;PARDINI, CARLA MARIA FRANCESCA;VAGLINI, FRANCESCA
2015-01-01
Abstract
Parkinson disease (PD) is a complex neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons. We used an in vitro rotenone-induced PD mouse model to verify the neuroprotective effects of C3, an exoenzyme produced by Clostridium botulinum that inactivates RhoA by ADP-ribosylation. Our data indicate that the inhibition of RhoA by C3 is able to partially rescue the rotenone induced damage by probably preventing microtubules depolymerization.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
