In the present study we performed ultrastructural dissection of cell-to-cell communication in vitro using an experimental model of glioblastoma multiforme. This experimental approach was combined with immunocytochemistry and staining for glycated end products. Evidence was provided showing an increased amount of misfolded proteins including prion protein and alpha synuclein which are released in the form of glycated compounds.
Altered intercellular diffusion of misfolded proteins in neuroglia.
RYSKALIN, LARISA;FERRUCCI, MICHELA;FULCERI, FEDERICA;BARTALUCCI, ALESSIA;NATALE, GIANFRANCO;RUFFOLI, RICCARDO;SOLDANI, PAOLA;GESI, MARCO;FORNAI, FRANCESCO
2015-01-01
Abstract
In the present study we performed ultrastructural dissection of cell-to-cell communication in vitro using an experimental model of glioblastoma multiforme. This experimental approach was combined with immunocytochemistry and staining for glycated end products. Evidence was provided showing an increased amount of misfolded proteins including prion protein and alpha synuclein which are released in the form of glycated compounds.File in questo prodotto:
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