The present study investigated the influence of nano-TiO2 (1 mg L1) on 2,3,7,8-tetrachlorodibenzo-pdioxin (2,3,7,8-TCDD) (46 pg L1) bioconcentration and toxicity in the European sea bass (Dicentrarchus labrax) during 7 days in vivo exposure. A multimarkers approach was applied in different organs: detoxification in liver; innate immunity and pro-inflammatory response and adaptive immunity in gills and spleen; genotoxicity in peripheral erythrocytes and muscle. Bioconcentration of 2,3,7,8-TCDD in presence of nano-TiO2 was investigated in liver, skin and muscle as well as interaction between nano- TiO2 and organic pollutants in artificial sea water (ASW). Nano-TiO2 negatively influenced immune response induced by 2,3,7,8-TCDD in spleen but not in gills and reduced the DNA damage induced by 2,3,7,8-TCDD in erythrocytes. nano-TiO2 did not interfere with 2,3,7,8-TCDD detoxification and bioconcentration according to the observed no interaction of the nano-TiO2 with organic pollutants in ASW.
|Autori:||Della Torre Camilla ; Buonocore Francesco; Frenzilli Giada; Corsolini Simonetta; Brunelli, Andrea; Guidi Patrizia; Kocan Anton; Mariottini Michela; Mottola Filomena; Nigro Marco; Pozo Karla; Randelli Elisa; Vannuccini Maria Luisa; Picchietti Simona; Santonastaso Marianna, Scarcelli Vittoria; Focardi Silvano; Marcomini Antonio, Rocco Lucia; Scapigliati Giuseppe; Corsi Ilaria|
|Titolo:||Influence of titanium dioxide nanoparticles on 2,3,7,8-tetrachlorodibenzo-p-dioxin bioconcentration and toxicity in the marine fish European sea bass (Dicentrarchus labrax)|
|Anno del prodotto:||2015|
|Digital Object Identifier (DOI):||10.1016/j.envpol.2014.09.020|
|Appare nelle tipologie:||1.1 Articolo in rivista|