The present study investigated the influence of nano-TiO2 (1 mg L1) on 2,3,7,8-tetrachlorodibenzo-pdioxin (2,3,7,8-TCDD) (46 pg L1) bioconcentration and toxicity in the European sea bass (Dicentrarchus labrax) during 7 days in vivo exposure. A multimarkers approach was applied in different organs: detoxification in liver; innate immunity and pro-inflammatory response and adaptive immunity in gills and spleen; genotoxicity in peripheral erythrocytes and muscle. Bioconcentration of 2,3,7,8-TCDD in presence of nano-TiO2 was investigated in liver, skin and muscle as well as interaction between nano- TiO2 and organic pollutants in artificial sea water (ASW). Nano-TiO2 negatively influenced immune response induced by 2,3,7,8-TCDD in spleen but not in gills and reduced the DNA damage induced by 2,3,7,8-TCDD in erythrocytes. nano-TiO2 did not interfere with 2,3,7,8-TCDD detoxification and bioconcentration according to the observed no interaction of the nano-TiO2 with organic pollutants in ASW.

Influence of titanium dioxide nanoparticles on 2,3,7,8-tetrachlorodibenzo-p-dioxin bioconcentration and toxicity in the marine fish European sea bass (Dicentrarchus labrax)

FRENZILLI, GIADA;GUIDI, PATRIZIA;NIGRO, MARCO;
2015

Abstract

The present study investigated the influence of nano-TiO2 (1 mg L1) on 2,3,7,8-tetrachlorodibenzo-pdioxin (2,3,7,8-TCDD) (46 pg L1) bioconcentration and toxicity in the European sea bass (Dicentrarchus labrax) during 7 days in vivo exposure. A multimarkers approach was applied in different organs: detoxification in liver; innate immunity and pro-inflammatory response and adaptive immunity in gills and spleen; genotoxicity in peripheral erythrocytes and muscle. Bioconcentration of 2,3,7,8-TCDD in presence of nano-TiO2 was investigated in liver, skin and muscle as well as interaction between nano- TiO2 and organic pollutants in artificial sea water (ASW). Nano-TiO2 negatively influenced immune response induced by 2,3,7,8-TCDD in spleen but not in gills and reduced the DNA damage induced by 2,3,7,8-TCDD in erythrocytes. nano-TiO2 did not interfere with 2,3,7,8-TCDD detoxification and bioconcentration according to the observed no interaction of the nano-TiO2 with organic pollutants in ASW.
Della Torre, Camilla; Buonocore, Francesco; Frenzilli, Giada; Corsolini, Simonetta; Brunelli, Andrea; Guidi, Patrizia; Kocan, Anton; Mariottini, Michela; Mottola, Filomena; Nigro, Marco; Pozo, Karla; Randelli, Elisa; Vannuccini Maria, Luisa; Picchietti, Simona; Santonastaso Marianna, Scarcelli Vittoria; Focardi, Silvano; Marcomini Antonio, Rocco Lucia; Scapigliati, Giuseppe; Corsi, Ilaria
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/755716
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