The prepn. of the triazole ester I (X = CH2), a methylenic bioisoster of an oxygenated compd. I (X = O), effective inhibitor of the prostaglandin synthesis in vitro is reported.  Biol. evaluation of I (X = CH2) and of the corresponding acid shows that the compds. maintain a good enzymic inhibitory activity compared with indomethacin and aspirin.

An 1,2,3-Triazole Derivative Bioisoster of a Potent in Vitro Prostaglandin Synthesis Inhibitor: Preparation and Biological Activity

BIAGI, GIULIANA;GIORGI, IRENE;LIVI, ORESTE;SCARTONI, VALERIO
1992-01-01

Abstract

The prepn. of the triazole ester I (X = CH2), a methylenic bioisoster of an oxygenated compd. I (X = O), effective inhibitor of the prostaglandin synthesis in vitro is reported.  Biol. evaluation of I (X = CH2) and of the corresponding acid shows that the compds. maintain a good enzymic inhibitory activity compared with indomethacin and aspirin.
Biagi, Giuliana; Dell'Omodarme, Giuliana; Giorgi, Irene; Livi, Oreste; Scartoni, Valerio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/755972
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