The prepn. of the triazole ester I (X = CH2), a methylenic bioisoster of an oxygenated compd. I (X = O), effective inhibitor of the prostaglandin synthesis in vitro is reported. Biol. evaluation of I (X = CH2) and of the corresponding acid shows that the compds. maintain a good enzymic inhibitory activity compared with indomethacin and aspirin.
An 1,2,3-Triazole Derivative Bioisoster of a Potent in Vitro Prostaglandin Synthesis Inhibitor: Preparation and Biological Activity
BIAGI, GIULIANA;GIORGI, IRENE;LIVI, ORESTE;SCARTONI, VALERIO
1992-01-01
Abstract
The prepn. of the triazole ester I (X = CH2), a methylenic bioisoster of an oxygenated compd. I (X = O), effective inhibitor of the prostaglandin synthesis in vitro is reported. Biol. evaluation of I (X = CH2) and of the corresponding acid shows that the compds. maintain a good enzymic inhibitory activity compared with indomethacin and aspirin.File in questo prodotto:
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