The nucleus locus coeruleus is the main noradrenergic nucleus in the central nervous system. Several evidences have been produced in the last decades converging in showing a critical role of locus coeruleus in different models of experimental seizures. As a general rule, it has been assumed that an increase in the “tone” of brain noradrenaline bears anticonvulsant effects, while its decrease makes animals more prone to epilepsy and seizures.
The role of locus coeruleus in experimental models of seizures and status epilepticus
Filippo Sean Giorgi1, 2;MURRI, LUIGI;
2009-01-01
Abstract
The nucleus locus coeruleus is the main noradrenergic nucleus in the central nervous system. Several evidences have been produced in the last decades converging in showing a critical role of locus coeruleus in different models of experimental seizures. As a general rule, it has been assumed that an increase in the “tone” of brain noradrenaline bears anticonvulsant effects, while its decrease makes animals more prone to epilepsy and seizures.File in questo prodotto:
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