The molecular profile of thyroid tumors can be discovered today in at least 70–80% of cases. The most common alterations are point mutations of BRAF and RAS followed by RET/PTC rearrangements. Other less frequent oncogenes involved are PIK3CA, TP53, TSHR, PTEN, GNAS, and CTNNB1 (1), but taken together they are still not able to account for 100% of cases.
Molecular profiles of papillary thyroid tumors have been changing in the last decades: How could we explain it?
ELISEI, ROSSELLA
2014-01-01
Abstract
The molecular profile of thyroid tumors can be discovered today in at least 70–80% of cases. The most common alterations are point mutations of BRAF and RAS followed by RET/PTC rearrangements. Other less frequent oncogenes involved are PIK3CA, TP53, TSHR, PTEN, GNAS, and CTNNB1 (1), but taken together they are still not able to account for 100% of cases.File in questo prodotto:
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