The present study is focused on the exploitation and conversion of sulphated polysaccharides obtainedfrom waste algal biomass into high value added material for biomedical applications. ulvan, a sulphatedpolysaccharide extracted from green seaweeds belonging to Ulva sp. was selected as a suitable materialdue to its chemical versatility and widely ascertained bioactivity. To date the present work representsthe first successful attempt of preparation of ulvan-based hydrogels displaying thermogelling behaviour.ulvan was provided with thermogelling properties by grafting poly(N-isopropylacrylamide) chains ontoits backbone as thermosensitive component. To this aim ulvan was properly modified with acryloylgroups to act as macroinitiator in the radical polymerization of N-isopropylacrylamide, induced by UVirradiation through a “grafting from” method. The thermogelling properties of the copolymer were inves-tigated by thermal and rheological analyses. Sol–gel transition of the copolymer was found to occur at30–31◦C thus indicating the feasibility of ulvan for being used as in-situ hydrogel forming systems forbiomedical applications

Design, preparation and characterization of ulvan based thermosensitive hydrogels

MORELLI, ANDREA;PUPPI, DARIO;CHIELLINI, FEDERICA
2016

Abstract

The present study is focused on the exploitation and conversion of sulphated polysaccharides obtainedfrom waste algal biomass into high value added material for biomedical applications. ulvan, a sulphatedpolysaccharide extracted from green seaweeds belonging to Ulva sp. was selected as a suitable materialdue to its chemical versatility and widely ascertained bioactivity. To date the present work representsthe first successful attempt of preparation of ulvan-based hydrogels displaying thermogelling behaviour.ulvan was provided with thermogelling properties by grafting poly(N-isopropylacrylamide) chains ontoits backbone as thermosensitive component. To this aim ulvan was properly modified with acryloylgroups to act as macroinitiator in the radical polymerization of N-isopropylacrylamide, induced by UVirradiation through a “grafting from” method. The thermogelling properties of the copolymer were inves-tigated by thermal and rheological analyses. Sol–gel transition of the copolymer was found to occur at30–31◦C thus indicating the feasibility of ulvan for being used as in-situ hydrogel forming systems forbiomedical applications
Morelli, Andrea; Betti, Margherita; Puppi, Dario; Chiellini, Federica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/757710
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