The present study is focused on the exploitation and conversion of sulphated polysaccharides obtainedfrom waste algal biomass into high value added material for biomedical applications. ulvan, a sulphatedpolysaccharide extracted from green seaweeds belonging to Ulva sp. was selected as a suitable materialdue to its chemical versatility and widely ascertained bioactivity. To date the present work representsthe first successful attempt of preparation of ulvan-based hydrogels displaying thermogelling behaviour.ulvan was provided with thermogelling properties by grafting poly(N-isopropylacrylamide) chains ontoits backbone as thermosensitive component. To this aim ulvan was properly modified with acryloylgroups to act as macroinitiator in the radical polymerization of N-isopropylacrylamide, induced by UVirradiation through a “grafting from” method. The thermogelling properties of the copolymer were inves-tigated by thermal and rheological analyses. Sol–gel transition of the copolymer was found to occur at30–31◦C thus indicating the feasibility of ulvan for being used as in-situ hydrogel forming systems forbiomedical applications
Design, preparation and characterization of ulvan based thermosensitive hydrogels
MORELLI, ANDREA;PUPPI, DARIO;CHIELLINI, FEDERICA
2016-01-01
Abstract
The present study is focused on the exploitation and conversion of sulphated polysaccharides obtainedfrom waste algal biomass into high value added material for biomedical applications. ulvan, a sulphatedpolysaccharide extracted from green seaweeds belonging to Ulva sp. was selected as a suitable materialdue to its chemical versatility and widely ascertained bioactivity. To date the present work representsthe first successful attempt of preparation of ulvan-based hydrogels displaying thermogelling behaviour.ulvan was provided with thermogelling properties by grafting poly(N-isopropylacrylamide) chains ontoits backbone as thermosensitive component. To this aim ulvan was properly modified with acryloylgroups to act as macroinitiator in the radical polymerization of N-isopropylacrylamide, induced by UVirradiation through a “grafting from” method. The thermogelling properties of the copolymer were inves-tigated by thermal and rheological analyses. Sol–gel transition of the copolymer was found to occur at30–31◦C thus indicating the feasibility of ulvan for being used as in-situ hydrogel forming systems forbiomedical applicationsFile | Dimensione | Formato | |
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