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EnglishThe present study is focused on the exploitation and conversion of sulphated polysaccharides obtainedfrom waste algal biomass into high value added material for biomedical applications. ulvan, a sulphatedpolysaccharide extracted from green seaweeds belonging to Ulva sp. was selected as a suitable materialdue to its chemical versatility and widely ascertained bioactivity. To date the present work representsthe first successful attempt of preparation of ulvan-based hydrogels displaying thermogelling behaviour.ulvan was provided with thermogelling properties by grafting poly(N-isopropylacrylamide) chains ontoits backbone as thermosensitive component. To this aim ulvan was properly modified with acryloylgroups to act as macroinitiator in the radical polymerization of N-isopropylacrylamide, induced by UVirradiation through a “grafting from” method. The thermogelling properties of the copolymer were inves-tigated by thermal and rheological analyses. Sol–gel transition of the copolymer was found to occur at30–31◦C thus indicating the feasibility of ulvan for being used as in-situ hydrogel forming systems forbiomedical applications
| Autori interni: | |
| Autori: | Morelli, Andrea; Betti, Margherita; Puppi, Dario; Chiellini, Federica |
| Titolo: | Design, preparation and characterization of ulvan based thermosensitive hydrogels |
| Anno del prodotto: | 2016 |
| Abstract: | The present study is focused on the exploitation and conversion of sulphated polysaccharides obtainedfrom waste algal biomass into high value added material for biomedical applications. ulvan, a sulphatedpolysaccharide extracted from green seaweeds belonging to Ulva sp. was selected as a suitable materialdue to its chemical versatility and widely ascertained bioactivity. To date the present work representsthe first successful attempt of preparation of ulvan-based hydrogels displaying thermogelling behaviour.ulvan was provided with thermogelling properties by grafting poly(N-isopropylacrylamide) chains ontoits backbone as thermosensitive component. To this aim ulvan was properly modified with acryloylgroups to act as macroinitiator in the radical polymerization of N-isopropylacrylamide, induced by UVirradiation through a “grafting from” method. The thermogelling properties of the copolymer were inves-tigated by thermal and rheological analyses. Sol–gel transition of the copolymer was found to occur at30–31◦C thus indicating the feasibility of ulvan for being used as in-situ hydrogel forming systems forbiomedical applications |
| Digital Object Identifier (DOI): | 10.1016/j.carbpol.2015.09.068 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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