Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT fraction accumulates in atherosclerotic plaques, and correlates with other histological markers of vulnerability. The present study was aimed to evaluate whether macrophagic lineage cells may provide a source of b-GGT within the atherosclerotic plaque.
Monocytes/macrophages activation contributes to b-gamma-glutamyltransferase accumulation inside atherosclerotic plaques
BELCASTRO, EUGENIA;FRANZINI, MARIA;CIANCHETTI, SILVANA;LORENZINI, EVELINA;FIERABRACCI, VANNA;POMPELLA, ALFONSO;CORTI, ALESSANDRO
2015-01-01
Abstract
Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT fraction accumulates in atherosclerotic plaques, and correlates with other histological markers of vulnerability. The present study was aimed to evaluate whether macrophagic lineage cells may provide a source of b-GGT within the atherosclerotic plaque.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
J Transl Med 2015.pdf
accesso aperto
Descrizione: Articolo principale
Tipologia:
Versione finale editoriale
Licenza:
Creative commons
Dimensione
3.65 MB
Formato
Adobe PDF
|
3.65 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
