Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT fraction accumulates in atherosclerotic plaques, and correlates with other histological markers of vulnerability. The present study was aimed to evaluate whether macrophagic lineage cells may provide a source of b-GGT within the atherosclerotic plaque.

Monocytes/macrophages activation contributes to b-gamma-glutamyltransferase accumulation inside atherosclerotic plaques

BELCASTRO, EUGENIA;FRANZINI, MARIA;CIANCHETTI, SILVANA;LORENZINI, EVELINA;FIERABRACCI, VANNA;POMPELLA, ALFONSO;CORTI, ALESSANDRO
2015-01-01

Abstract

Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT fraction accumulates in atherosclerotic plaques, and correlates with other histological markers of vulnerability. The present study was aimed to evaluate whether macrophagic lineage cells may provide a source of b-GGT within the atherosclerotic plaque.
2015
Belcastro, Eugenia; Franzini, Maria; Cianchetti, Silvana; Lorenzini, Evelina; Masotti, Silvia; Fierabracci, Vanna; Pucci, Angela; Pompella, Alfonso; Corti, Alessandro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/758187
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