To evaluate the toxicokinetics and persistence of residues of melamine (MEL) in ducks, MEL was administered intravenously (i.v.) or orally (p.o.) to ducks at a dosage of 5.5 mg/kg body weight. The concentration of MEL in theplasma and various tissues was detected using HPLC equipped with an ultraviolet detector . The plasma concentration of MEL in ducks was determined up to 12 h after both i.v. and p.o. adm inistrations. The average value of elimination half-life ( t1/2b) of MEL was 2.16 0.37 and 2.01 0.56 h after i.v. and p.o. administration , respectively . The absolute p.o. bioavailability was 90.79%. MEL was measurable in the liver and kidney after p.o. administration with maximum levels of 15.80 1.81 and 15.49 2.12 lg/g at 6 h, respectively. The results suggest that most of the administered MEL is efﬁciently absorbed from the gastro intestinal tract, and it has the ability to distribute into various tissues of the duck.
|Autori:||Suknikom, P.; Jermnak, U.; Poapolathep, S.; Isariyodom, S.; Giorgi, M.; Kumagai, S.; Poapolathep, A.|
|Titolo:||Dispositions and Tissue Depletion of Melamine in Ducks|
|Anno del prodotto:||2016|
|Digital Object Identifier (DOI):||10.1111/jvp.12242|
|Appare nelle tipologie:||1.1 Articolo in rivista|