Mono- and bis-alkaloid chiral auxiliaries with anthraquinone or phenanthryl cores were probed as chiral solvating agents (CSAs) for the enantiodiscrimination of chiral cyclic hemiesters. The dimeric anthraquinone deriv. and the monomeric phenanthryl one showed remarkable efficiency in the NMR (NMR) differentiation of enantiomeric mixts. of hemiesters. An anthraquinone analogous with a single alkaloid unit was remarkably less effective. The conformational prevalence of the chiral auxiliaries were ascertained by NMR.
Monomeric and Dimeric 9-O Anthraquinone and Phenanthryl Derivatives of Cinchona Alkaloids as Chiral Solvating Agents for the NMR Enantiodiscrimination of Chiral Hemiesters
UCCELLO BARRETTA, GLORIA;MANDOLI, ALESSANDRO;BALZANO, FEDERICA;
2015-01-01
Abstract
Mono- and bis-alkaloid chiral auxiliaries with anthraquinone or phenanthryl cores were probed as chiral solvating agents (CSAs) for the enantiodiscrimination of chiral cyclic hemiesters. The dimeric anthraquinone deriv. and the monomeric phenanthryl one showed remarkable efficiency in the NMR (NMR) differentiation of enantiomeric mixts. of hemiesters. An anthraquinone analogous with a single alkaloid unit was remarkably less effective. The conformational prevalence of the chiral auxiliaries were ascertained by NMR.File in questo prodotto:
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