Joint involvement is a common manifestation of systemic lupus erythematosus (SLE) and is described as a non-erosive mild synovitis. However some SLE patients may present a more severe joint involvement requiring aggressive therapy. We describe the case of a SLE patient with a severe arthritis unresponsive to methotrexate, successfully treated with anti-TNF-alpha drug as induction therapy and we report the results of a systematic literature review on the use of TNF-alpha inhibitors in SLE.
TNF-alpha inhibitors in Systemic Lupus Erythematosus. A case report and a systematic literature review
MOSCA, MARTA;TANI, CHIARA;CARLI, LINDA;DELLE SEDIE, ANDREA;VAGNANI, SABRINA;BALDINI, CHIARA;BOMBARDIERI, STEFANO
2015-01-01
Abstract
Joint involvement is a common manifestation of systemic lupus erythematosus (SLE) and is described as a non-erosive mild synovitis. However some SLE patients may present a more severe joint involvement requiring aggressive therapy. We describe the case of a SLE patient with a severe arthritis unresponsive to methotrexate, successfully treated with anti-TNF-alpha drug as induction therapy and we report the results of a systematic literature review on the use of TNF-alpha inhibitors in SLE.File in questo prodotto:
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