Mesenchymal stromal cells (MSCs) modulate the immune response and represent a potential treatment for inflammatory and autoimmune diseases. We hypothesized that this feature could be potentiated by co-administering anti-inflammatory cytokines. In this article, we asked whether engineering of Wharton Jelly-derived human MSCs (WJ-hMSCs) to express an anti-inflammatory cytokine increases cell immunomodulatory properties without altering their native features.
Human Wharton's jelly-derived mesenchymal stromal cells engineered to secrete Epstein-Barr virus interleukin-10 show enhanced immunosuppressive properties
QUARANTA, PAOLAFormal Analysis
;FOCOSI, DANIELEWriting – Original Draft Preparation
;DI IESU, MARILENAFormal Analysis
;STAMPACCHIA, GIULIAMethodology
;PAOLICCHI, ALDOFormal Analysis
;SCATENA, FABRIZIOWriting – Original Draft Preparation
;FREER, GIULIAWriting – Review & Editing
;PISTELLO, MAURO
Writing – Review & Editing
2016-01-01
Abstract
Mesenchymal stromal cells (MSCs) modulate the immune response and represent a potential treatment for inflammatory and autoimmune diseases. We hypothesized that this feature could be potentiated by co-administering anti-inflammatory cytokines. In this article, we asked whether engineering of Wharton Jelly-derived human MSCs (WJ-hMSCs) to express an anti-inflammatory cytokine increases cell immunomodulatory properties without altering their native features.File in questo prodotto:
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Cytotherapy paper.pdf
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