Mesenchymal stromal cells (MSCs) modulate the immune response and represent a potential treatment for inflammatory and autoimmune diseases. We hypothesized that this feature could be potentiated by co-administering anti-inflammatory cytokines. In this article, we asked whether engineering of Wharton Jelly-derived human MSCs (WJ-hMSCs) to express an anti-inflammatory cytokine increases cell immunomodulatory properties without altering their native features.

Human Wharton's jelly-derived mesenchymal stromal cells engineered to secrete Epstein-Barr virus interleukin-10 show enhanced immunosuppressive properties

QUARANTA, PAOLA
Formal Analysis
;
FOCOSI, DANIELE
Writing – Original Draft Preparation
;
DI IESU, MARILENA
Formal Analysis
;
STAMPACCHIA, GIULIA
Methodology
;
PAOLICCHI, ALDO
Formal Analysis
;
SCATENA, FABRIZIO
Writing – Original Draft Preparation
;
FREER, GIULIA
Writing – Review & Editing
;
PISTELLO, MAURO
Writing – Review & Editing
2016-01-01

Abstract

Mesenchymal stromal cells (MSCs) modulate the immune response and represent a potential treatment for inflammatory and autoimmune diseases. We hypothesized that this feature could be potentiated by co-administering anti-inflammatory cytokines. In this article, we asked whether engineering of Wharton Jelly-derived human MSCs (WJ-hMSCs) to express an anti-inflammatory cytokine increases cell immunomodulatory properties without altering their native features.
2016
Quaranta, Paola; Focosi, Daniele; DI IESU, Marilena; Cursi, Chiara; Zucca, Alessandra; Curcio, Michele; Lapi, Simone; Boldrini, Linda; Stampacchia, Gi...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/769058
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