T cell subsets and thyroid-stimulating antibodies in patients with Graves’ disease in clinical remission

Patients with active Graves’ disease almost constantly show phenotypic alterations of T lymphocytes, such as an increase of “activated” cells recognized by various surface markers (e.g. la antigens). Such alterations are present in a certain number of apparently cured patients. The data herein reported refer to 25 patients with Graves’ disease in clinical remission, in whom we have attempted to correlateT cell subset imbalances, the presence of thyroid-stimulating antibodies (TSAb) and the outcome of the subsequent relapse. The results obtained show a significant association between TSAb and the increase of Ia-positive T cells: no relationship was found between TSAb and other T lymphocyte subsets. One-year clinical follow-up of the patients enabled us to see relapses of hyperthyroidism in only two patients, who had shown in the first control both TSAb positivity and increased la-positive T cells. These results, in our opinion, suggest a role of Ia antigens expression on T lymphocytes in the clinical course of Graves’ disease.