Giant cell hepatitis withautoimmune haemolytic anaemia (GCH-AHA) is a rare and aggressive disease of infancy and may have fatal prognosis. It is presumed to be an autoimmune disease, but the mechanism of liver injury is unknown. Immunosuppressive therapy may results in remission in mild forms while in severe forms, B cell depletion with rituximab can be an option. Liver transplantation may be a rescue treatment but relapse can occur in the graft.
L'epatite gigantocellulare associata ad anemia emolitica autoimmune
NASTASIO, SILVIA;MAGGIORE, GIUSEPPE
2014-01-01
Abstract
Giant cell hepatitis withautoimmune haemolytic anaemia (GCH-AHA) is a rare and aggressive disease of infancy and may have fatal prognosis. It is presumed to be an autoimmune disease, but the mechanism of liver injury is unknown. Immunosuppressive therapy may results in remission in mild forms while in severe forms, B cell depletion with rituximab can be an option. Liver transplantation may be a rescue treatment but relapse can occur in the graft.File in questo prodotto:
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