Atmospheric pressure photoionization (APPI) is the last arrival in the family of atmospheric pressure ionization (API) methods to couple mass spectrometry (MS) to liquid-phase separation techniques. The basic idea was to further extend the fields of application of liquid chromatography (LC)–MS to those molecules that are not, or are poorly amenable, to electrospray (ESI) or APCI. The present review explores the literature. After a short introduction with an historical background and the premises for its development, we describe the technique, its physical principles, and the factors that affect its efficiency. The review also presents a survey of applications in different fields.
|Autori interni:||SABA, ALESSANDRO|
|Autori:||Raffaelli A; Saba A|
|Titolo:||Atmospheric pressure photoionization mass spectrometry|
|Anno del prodotto:||2003|
|Digital Object Identifier (DOI):||10.1002/mas.10060|
|Appare nelle tipologie:||1.1 Articolo in rivista|