The main causative agent of dermatophytosis is Trichophyton rubrum, a widespread filamentous fungus that can infect keratinized tissue such as skin, nails and hair. T rubrum is known to account for almost 70% of all dermatophyte infections. Several antifungal drugs have become available for the treatment of dermatophytosis and among these, terbinafine (TRB), amorolfine (AMF), itraconazole (ITC), and ciclopirox (CPX) are the most frequently used to treat T rubrum infections. Although, therapeutic strategies based on the use of TRB, AMF, ITC or CPX are generally considered effective, the onset of resistant strains against some of these antifungal agents has been reported.
In vitro evaluation of the potential of ciclopirox to induce resistance in Trichophyton rubrum, in comparison to terbinafine, amorolfine, and itraconazole
GHELARDI, EMILIA;CELANDRONI, FRANCESCO;
2013-01-01
Abstract
The main causative agent of dermatophytosis is Trichophyton rubrum, a widespread filamentous fungus that can infect keratinized tissue such as skin, nails and hair. T rubrum is known to account for almost 70% of all dermatophyte infections. Several antifungal drugs have become available for the treatment of dermatophytosis and among these, terbinafine (TRB), amorolfine (AMF), itraconazole (ITC), and ciclopirox (CPX) are the most frequently used to treat T rubrum infections. Although, therapeutic strategies based on the use of TRB, AMF, ITC or CPX are generally considered effective, the onset of resistant strains against some of these antifungal agents has been reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
