Histidine-rich glycoprotein (HRG) is a plasma glycoprotein that exhibits many modulatory functions in biological processes, including coagulation and immune response. To date, HRG levels have been investigated in the serum and plasma of patients with different systemic autoimmune diseases but no data are available on salivary HRG expression in autoimmunity. Primary Sjögren’s syndrome (pSS) represents a model of systemic autoimmune disorder affecting the major salivary glands.This pilot study is the first to have described salivary HRG in pSS samples, supporting the potentialities of proteomics in discovering autoimmunity biomarkers.
Salivary histidine-rich glycoprotein: a novel putative biomarker for autoimmune disease.
MARTINI, DANIELA;SERNISSI, FRANCESCA;SABBATINI, ANTONIETTA RAFFAELLA MARIA;BALDINI, CHIARA;GIACOMELLI, CAMILLO;BOMBARDIERI, STEFANO;RAGGI, ANTONIO
2013-01-01
Abstract
Histidine-rich glycoprotein (HRG) is a plasma glycoprotein that exhibits many modulatory functions in biological processes, including coagulation and immune response. To date, HRG levels have been investigated in the serum and plasma of patients with different systemic autoimmune diseases but no data are available on salivary HRG expression in autoimmunity. Primary Sjögren’s syndrome (pSS) represents a model of systemic autoimmune disorder affecting the major salivary glands.This pilot study is the first to have described salivary HRG in pSS samples, supporting the potentialities of proteomics in discovering autoimmunity biomarkers.File in questo prodotto:
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