N-trimethylchitosan (TMCh) and N-carboxymethyl chitosan (CMCh) were synthesized from a chitosan (Ch) of high MW and deacetylation degree. 1% TMCh and, to a lesser degree, 1% Ch HCl in ophthalmic solutions enhanced transcorneal absorption of ofloxacin in rabbits. 1% CMCh did not enhance drug absorption, but mediated zero-order absorption kinetics leading to a time-constant effective antibiotic level in the aqueous.
Effects of chitosan and of its N-trimethyl and N-carboxymethyl derivatives on the ocular pharmacokinetics of ofloxacin in rabbits
DI COLO, GIACOMO;ZAMBITO, YLENIA;BURGALASSI, SUSI;SAETTONE, MARCO FABRIZIO
2003-01-01
Abstract
N-trimethylchitosan (TMCh) and N-carboxymethyl chitosan (CMCh) were synthesized from a chitosan (Ch) of high MW and deacetylation degree. 1% TMCh and, to a lesser degree, 1% Ch HCl in ophthalmic solutions enhanced transcorneal absorption of ofloxacin in rabbits. 1% CMCh did not enhance drug absorption, but mediated zero-order absorption kinetics leading to a time-constant effective antibiotic level in the aqueous.File in questo prodotto:
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