Cu(I) catalyzed, Huisgen azide/alkyne 1,3-dipolar cycloaddition (CuAAC) is recognized as the tool of choice for ligating organic molecules in a numerous fields. Out of several catalytic systems used for CuAAC reaction, the choice of supported Cu catalysts captured the attention of many workers to minimize the copper content in the final products. Nonetheless almost all the studies do not provide any straightforward method to reduce the Cu contamination in final product. The use of appropriate support and continuous-flow conditions could contribute to solve this problem. Here we report the use of novel Cu nanoparticles obtained by metal vapour synthesis (MVS) supported on commercial aminopropyl-fuctionalized silica (APSiO2) as a catalyst for CuAAC reaction in continuous-flow conditions.
Aminopropyl-silica supported Cu nanoparticles: an efficient catalyst for continuous-flow Huisgen azide-alkyne cycloaddtion (CuAAC)
MANDOLI, ALESSANDRO;
2014-01-01
Abstract
Cu(I) catalyzed, Huisgen azide/alkyne 1,3-dipolar cycloaddition (CuAAC) is recognized as the tool of choice for ligating organic molecules in a numerous fields. Out of several catalytic systems used for CuAAC reaction, the choice of supported Cu catalysts captured the attention of many workers to minimize the copper content in the final products. Nonetheless almost all the studies do not provide any straightforward method to reduce the Cu contamination in final product. The use of appropriate support and continuous-flow conditions could contribute to solve this problem. Here we report the use of novel Cu nanoparticles obtained by metal vapour synthesis (MVS) supported on commercial aminopropyl-fuctionalized silica (APSiO2) as a catalyst for CuAAC reaction in continuous-flow conditions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
