The effect of chemotherapy on the outcome of allograft reconstruction proceduresafter resection of bone tumors is of considerable interest in the light of both experimental and clinical evidence suggesting that it has an adverse effect on bon repair. The crucial clinical issue, however, is whether the failure of allograft reconstruction due to infection, fracture or both, is especially frequent when performed concomitant with administration of chemotherapy. We addressed this question by evaluating the clinical results and complications of segmental allograft replacement in a gorup of young patients who were followed prospectively and of whom the majority had high grade sarcomas and were treated with neoadjuvant chemotherapy protocols.
Segmental allograft reconstruction concomitant with neoadjuvant chemotherapy
CAPANNA, RODOLFO;
1989-01-01
Abstract
The effect of chemotherapy on the outcome of allograft reconstruction proceduresafter resection of bone tumors is of considerable interest in the light of both experimental and clinical evidence suggesting that it has an adverse effect on bon repair. The crucial clinical issue, however, is whether the failure of allograft reconstruction due to infection, fracture or both, is especially frequent when performed concomitant with administration of chemotherapy. We addressed this question by evaluating the clinical results and complications of segmental allograft replacement in a gorup of young patients who were followed prospectively and of whom the majority had high grade sarcomas and were treated with neoadjuvant chemotherapy protocols.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
