Psychotic symptoms are frequently reported in longitudinal studies on patients with Parkinson disease (PD).1 Hallucinations are the most common psychotic symptom in PD, especially in advanced stages of disease, with an estimated cumulative lifetime prevalence of 40% to 60%,2 and disease-related factors play an important role in their pathophysiology in this clinical population.2 Although delusions are less common in patients with PD and often represent a deterioration of hallucinations,2 isolated delusions have been recently described in cognitively preserved patients with PD,3 and recent empirical findings,4,5 here presented and integrated, permit to shed light on their pathophysiology.
From aberrant salience to jumping to conclusions: Dopaminergic pathways to delusions in Parkinson disease
BONUCCELLI, UBALDO
2013-01-01
Abstract
Psychotic symptoms are frequently reported in longitudinal studies on patients with Parkinson disease (PD).1 Hallucinations are the most common psychotic symptom in PD, especially in advanced stages of disease, with an estimated cumulative lifetime prevalence of 40% to 60%,2 and disease-related factors play an important role in their pathophysiology in this clinical population.2 Although delusions are less common in patients with PD and often represent a deterioration of hallucinations,2 isolated delusions have been recently described in cognitively preserved patients with PD,3 and recent empirical findings,4,5 here presented and integrated, permit to shed light on their pathophysiology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.