Marbofloxacinisacommonlyusedantibioticdrugtotreatbacterial infectionsinpetanimals.Similarlyto other fluoroquinolones,marbofloxacin issubjecttotheemergingproblemofantimicrobialresistance.Thus,it is necessarytousepharmacokinetic/pharmacodynamics (PK/PD)integrationand modelingtominimizethe selection ofresistantmutantsofbacteriaandextend the usefullifeofantimicrobialagents,including marbofloxacin.ThisstudyevaluatedthePKsandtheinvivoefficacy ofmarbofloxacin in Trachemys scripta scripta after asingleintracoelomicinjection.Of8,3groups healthyadultturtleswereeachtreatedwith0.4,2, and 10mg/kgofmarbofloxacin. Bloodsamplesandrectal swabs werecollectedtomeasure Q7 marbofloxacin concentrations inserum(usinganhigh-performance liquidchromatographywith fluorescencedetection validated method)andtoevaluatein vitro antimicrobialsusceptibility (usingKirby-BauerMethod), respectively. ThePKprofiles ofmarbofloxacin fit abicompartmentalmodelandweredosedependent.The Tmax and half-liferangedbetween2.82to4.64hoursand16.14 to30.68hours,respectively.Bacteriaisolation showedthepresenceofboth Eschericacoli and Salmonella spp. Salmonella spp. wereisolatedonly48hoursafter the administrationofmarbofloxacin andallstrainswereconsideredresistant.Resultsseemtosuggestthateven if marbofloxacinisabletoreachconsiderableplasmaconcentrations, itcanstillbeineffectiveagainstbacteria that arepotentialanimalandhumanpathogens.
Blood concentrations of marbofloxacin and its in vivo effect in yellow-bellied slider turtles (Trachemys scripta scripta) after a single intracoelomic injection at 3 dose rates
GIORGI, MARIO
2016-01-01
Abstract
Marbofloxacinisacommonlyusedantibioticdrugtotreatbacterial infectionsinpetanimals.Similarlyto other fluoroquinolones,marbofloxacin issubjecttotheemergingproblemofantimicrobialresistance.Thus,it is necessarytousepharmacokinetic/pharmacodynamics (PK/PD)integrationand modelingtominimizethe selection ofresistantmutantsofbacteriaandextend the usefullifeofantimicrobialagents,including marbofloxacin.ThisstudyevaluatedthePKsandtheinvivoefficacy ofmarbofloxacin in Trachemys scripta scripta after asingleintracoelomicinjection.Of8,3groups healthyadultturtleswereeachtreatedwith0.4,2, and 10mg/kgofmarbofloxacin. Bloodsamplesandrectal swabs werecollectedtomeasure Q7 marbofloxacin concentrations inserum(usinganhigh-performance liquidchromatographywith fluorescencedetection validated method)andtoevaluatein vitro antimicrobialsusceptibility (usingKirby-BauerMethod), respectively. ThePKprofiles ofmarbofloxacin fit abicompartmentalmodelandweredosedependent.The Tmax and half-liferangedbetween2.82to4.64hoursand16.14 to30.68hours,respectively.Bacteriaisolation showedthepresenceofboth Eschericacoli and Salmonella spp. Salmonella spp. wereisolatedonly48hoursafter the administrationofmarbofloxacin andallstrainswereconsideredresistant.Resultsseemtosuggestthateven if marbofloxacinisabletoreachconsiderableplasmaconcentrations, itcanstillbeineffectiveagainstbacteria that arepotentialanimalandhumanpathogens.File | Dimensione | Formato | |
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Corrected proof Vercelli et al., 2016.pdf
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