There is an emerging interest in applying inorganic and organometallic transition metal complexes like new anticancer drug capable of interacting with DNA. Recently, studies have focused on half-sandwich Ir(III) anticancer complexes, that can attack the DNA or perturbate the redox status of cells. In this work we studied the interaction between the iridium complex shown in Figure 1 and biosubstrates as DNA, RNA and BSA. Firstly, the properties of the metal complex alone were analysed: the chloride exchange process (to give Ir-H₂O from Ir-Cl) and the acidity constants. Then, the possible binding reaction of the two species Ir-H₂O and Ir-OH¯, with biosubstrates was analysed through spectrophotometry, viscometry, circular dichroism and stopped-flow kinetics. The results obtained show some interesting interactions taking place, that will be discussed.
|Titolo:||Ir(III)-ciclopentadienyl-pyridinyl-quinoline complexes: solution properties and polynucleotides binding|
|Anno del prodotto:||2016|
|Appare nelle tipologie:||4.2 Abstract in Atti di convegno|