A new NHC iridium(I) complex showing significant antiproliferative properties in vitro is described here. Its crystal structure, solution behaviour and interactions with the model proteins cytochrome c (cyt c) and lysozyme were investigated. High resolution ESI-MS measurements suggest that this iridium(I) complex acts as a prodrug and binds cyt c tightly through an unusual “oxidative” mechanism. Eventually, an iridium(III)-NHC fragment is found associated to the protein
Cytotoxic activity and protein binding through an unusual oxidative mechanism by an iridium(I)–NHC complex
MARZO, TIZIANOPenultimo
;
2015-01-01
Abstract
A new NHC iridium(I) complex showing significant antiproliferative properties in vitro is described here. Its crystal structure, solution behaviour and interactions with the model proteins cytochrome c (cyt c) and lysozyme were investigated. High resolution ESI-MS measurements suggest that this iridium(I) complex acts as a prodrug and binds cyt c tightly through an unusual “oxidative” mechanism. Eventually, an iridium(III)-NHC fragment is found associated to the proteinFile in questo prodotto:
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Descrizione: Cytotoxic Activity and Protein Binding through an unusual oxidative mechanism by an Iridium(I)–NHC Complex
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