Frontotemporal dementia (FTD) is increasingly becoming recognizedas a major cause of early onset (< 65 years) neurodegenerativedementia. Although sleep disorders significantly impair patients´ andcaregivers´ quality of life in neurodegenerative diseases, polysomno-graphic data in FTD patients are scarce in literature. Aim of our studywas to investigate sleep microstructure in FTD, by means of CyclicAlternating Pattern (CAP), in a group of ten behavioral variant FTDpatients (6 M, 4 F; mean age 61.2  7.3 years; disease duration:1.4  0.7 years) and to compare them with cognitively intact healthyelderly and Alzheimer disease patients.Sleep in FTD patients was altered at different levels, involving notonly the conventional sleep parameters, but also microstructure.Compared with healthy controls, nocturnal sleep was at least asmuch impaired as observed in AD, and in a shorter disease duration,with decreased total sleep time and REM sleep, and increased lightsleep. CAP analysis pointed out increased sleep instability (CAPrate) for FTD, and a CAP disruption that most prominently involvedslow wave activity related phases while CAP rate was spared. Sleepspindle analysis confirm that sleep alteration in FTD go beyondconventional sleep paerameters.Sleep impairment in FTD may be specifically related to the specificfrontal lobe involvement in the neurodegenerative process. Thepattern of alterations seems somewhat peculiar, probably due to theanatomical distribution of the neurodegenerative process with amajor impact on frontal lobe generated sleep transients.

Non-rapid eye movement sleep instability in fronto-temporal dementia

MAESTRI, MICHELANGELO;CARNICELLI, LUCA;Giorgi, F. S.;BONUCCELLI, UBALDO;BONANNI, ENRICA
2016-01-01

Abstract

Frontotemporal dementia (FTD) is increasingly becoming recognizedas a major cause of early onset (< 65 years) neurodegenerativedementia. Although sleep disorders significantly impair patients´ andcaregivers´ quality of life in neurodegenerative diseases, polysomno-graphic data in FTD patients are scarce in literature. Aim of our studywas to investigate sleep microstructure in FTD, by means of CyclicAlternating Pattern (CAP), in a group of ten behavioral variant FTDpatients (6 M, 4 F; mean age 61.2  7.3 years; disease duration:1.4  0.7 years) and to compare them with cognitively intact healthyelderly and Alzheimer disease patients.Sleep in FTD patients was altered at different levels, involving notonly the conventional sleep parameters, but also microstructure.Compared with healthy controls, nocturnal sleep was at least asmuch impaired as observed in AD, and in a shorter disease duration,with decreased total sleep time and REM sleep, and increased lightsleep. CAP analysis pointed out increased sleep instability (CAPrate) for FTD, and a CAP disruption that most prominently involvedslow wave activity related phases while CAP rate was spared. Sleepspindle analysis confirm that sleep alteration in FTD go beyondconventional sleep paerameters.Sleep impairment in FTD may be specifically related to the specificfrontal lobe involvement in the neurodegenerative process. Thepattern of alterations seems somewhat peculiar, probably due to theanatomical distribution of the neurodegenerative process with amajor impact on frontal lobe generated sleep transients.
2016
https://onlinelibrary.wiley.com/toc/13652869/2016/25/S1
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/823137
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