Malignant pleural mesothelioma (MPM) is a relatively rare tumor, with the epithelioid type occurring more frequently. Several biomarkers have been suggested for screening and early diagnosis of MPM. Currently, high levels of soluble mesothelin-related peptides (SMRP), plasma osteopontin (pOPN) and vimentin have been reported in patients with MPM as promising markers for diagnosis, but their clinical use in monitoring is still discussed. The aim of our study was to evaluate the usefulness of these substances as markers of the clinical response to treatment in patients suffering from epithelioid mesothelioma.

Serum mesothelin, osteopontin and vimentin: useful markers for clinical monitoring of malignant pleural mesothelioma

BONOTTI, ALESSANDRA;PANTANI, ELENA;GIUSTI, LAURA;DONADIO, ELENA;MAZZONI, MARIA ROSA;LUCCHI, MARCO;MUSSI, ALFREDO;CRISTAUDO, ALFONSO;FODDIS, RUDY
2017-01-01

Abstract

Malignant pleural mesothelioma (MPM) is a relatively rare tumor, with the epithelioid type occurring more frequently. Several biomarkers have been suggested for screening and early diagnosis of MPM. Currently, high levels of soluble mesothelin-related peptides (SMRP), plasma osteopontin (pOPN) and vimentin have been reported in patients with MPM as promising markers for diagnosis, but their clinical use in monitoring is still discussed. The aim of our study was to evaluate the usefulness of these substances as markers of the clinical response to treatment in patients suffering from epithelioid mesothelioma.
2017
Bonotti, Alessandra; Simonini, Silvia; Pantani, Elena; Giusti, Laura; Donadio, Elena; Mazzoni, MARIA ROSA; Chella, Antonio; Marconi, Letizia; Ambrosin...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/825460
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