Abstract Atherosclerotic lesions are infiltrated by macrophages and T lymphocytes, potentially reactive to pathogens. We studied in vivo activated T lymphocytes that infiltrate atherosclerotic plaques of Helicobacter pylori-infected patients with or without anti-Chlamydia pneumoniae antibodies. In all atherosclerotic lesions, T helper type 1 (Th1) cells were predominant. C. pneumoniae-specific T cells were detected only in the plaques of anti-C. pneumoniae seropositive patients, whereas H. pylori-specific T cells were found in the gastric mucosa but not in the plaques of the same patients. Plaque-derived Th1 cells expressed cytotoxicity, proapoptotic activity, and help for monocyte tissue factor production. Although multifactorial, atherosclerosis can be regarded as a Th1-driven immunopathological condition.
|Autori:||BENAGIANO M; AZZURRI A; CIERVO A; AMEDEI A; TAMBUTINI C; FERRARI M; TELFORD J. L; BALDARI C. T; ROMAGNANI S; CASSONE A; DELIOS M. M; DEL PRETE G|
|Titolo:||T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions|
|Anno del prodotto:||2003|
|Digital Object Identifier (DOI):||10.1073/pnas.1135726100|
|Appare nelle tipologie:||1.1 Articolo in rivista|