Regorafenib and TAS-102 have recently demonstrated statistically significant survival gains in patients with refractory metastatic colorectal cancer (mCRC). Life expectancy ≥12 weeks was an inclusion criterion in registrative trials, and the identification of proper clinical selection tools for the daily use of these drugs in heavily pre-treated patients is needed to improve the cost-benefit ratio. We aimed at building a nomogram able to predict death probability within 12 weeks from the date of assessment of refractory mCRC.

Estimating 12-weeks death probability in patients with refractory metastatic colorectal cancer: the Colon Life nomogram

MARMORINO, FEDERICA;ROSSINI, DANIELE;LOUPAKIS, FOTIOS;FALCONE, ALFREDO;CREMOLINI, CHIARA
2017-01-01

Abstract

Regorafenib and TAS-102 have recently demonstrated statistically significant survival gains in patients with refractory metastatic colorectal cancer (mCRC). Life expectancy ≥12 weeks was an inclusion criterion in registrative trials, and the identification of proper clinical selection tools for the daily use of these drugs in heavily pre-treated patients is needed to improve the cost-benefit ratio. We aimed at building a nomogram able to predict death probability within 12 weeks from the date of assessment of refractory mCRC.
Pietrantonio, F; Miceli, R; Rimassa, L; Lonardi, S; Aprile, G; Mennitto, A; Marmorino, Federica; Bozzarelli, S; Antonuzzo, L; Tamburini, E; Morano, F; Rossini, Daniele; Battaglin, F; Baretti, M; Berenato, R; Formica, V; Mosconi, S; Petrelli, F; Ghidini, M; Loupakis, Fotios; Spada, D; Cinieri, S; Beretta, G; Falcone, Alfredo; de Braud, F; Cremolini, Chiara
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/828199
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