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EnglishWe have examined 44 cases of human colonic and rectal carcinomas for structural rearrangement and amplification of c-myc, N-myc, L-myc, c-myb and p53 oncogenes. DNA hybridization showed evidence of c-myc amplification in only one of the samples tested. In addition, the same tumour also showed a rearrangement immediately 3′ to the c-myc locus. No rearrangement could be found at the c-myc locus in the other 43 cases. Moreover, our molecular analysis of N-myc, L-myc, c-myb and p53 genes indicated no relevant alteration of the copy number and/or genomic structure of these nuclear oncogenes. Thus, at least in human colorectal malignancies, it is unlikely that nuclear oncogene structural alterations and/or amplification plays a major role in tumour induction or progression.
| Autori interni: | |
| Autori: | Dolcetti, R; DE RE, V; Viel, A; Pistello, Mauro; Tavian, M; Boiocchi, M. |
| Titolo: | NUCLEAR ONCOGENE AMPLIFICATION OR REARRANGEMENT IS NOT INVOLVED IN HUMAN COLORECTAL MALIGNANCIES |
| Anno del prodotto: | 1988 |
| Digital Object Identifier (DOI): | 10.1016/0277-5379(88)90223-4 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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