Salivary cystatin S is a defence protein mainly produced by submandibular glands and involved in innate oral immunity. This study aimed to verify whether cystatin S was diversely expressed in different disease subsets of primary Sjogren's syndrome (pSS) patients, defined on the basis of salivary flow [unstimulated salivary flow rate (USFR)], minor salivary gland (MSG) focus score and submandibular gland ultrasonography abnormalities. We also evaluated miR-126 and miR-335-5p expression in MSG biopsies to verify whether an aberrant regulation of cystatin S at the glandular level may influence its salivary expression.

Cystatin S-a candidate biomarker for severity of submandibular gland involvement in Sjögren's syndrome

CECCHETTINI, ANTONELLA;MOSCA, MARTA;BALDINI, CHIARA
2017

Abstract

Salivary cystatin S is a defence protein mainly produced by submandibular glands and involved in innate oral immunity. This study aimed to verify whether cystatin S was diversely expressed in different disease subsets of primary Sjogren's syndrome (pSS) patients, defined on the basis of salivary flow [unstimulated salivary flow rate (USFR)], minor salivary gland (MSG) focus score and submandibular gland ultrasonography abnormalities. We also evaluated miR-126 and miR-335-5p expression in MSG biopsies to verify whether an aberrant regulation of cystatin S at the glandular level may influence its salivary expression.
Martini, Daniela; Gallo, Alessia; Vella, Serena; Sernissi, Francesca; Cecchettini, Antonella; Luciano, Nicoletta; Polizzi, Enza; Conaldi, Pier Giulio; Mosca, Marta; Baldini, Chiara
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/850419
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