This report describes the identification of a novel DPB1 allele, DPB *9701, found in an Italian Caucasian individual. The new allele was detected by human leukocyte antigen sequence-based typing carried out to investigate the role of genetic factors in determining the outcome of hepatitis C virus infection. DPB1*9701 was identical to DPB1*0501 except for a single-nucleotide substitution at codon 43 (GGG --> TGG). This nucleotide change is a non-synonymous mutation and results in the amino acid substitution glycine (G) --> tryptophan (W). The nucleotide sequence has been deposited in GenBank under the accession number AY033075, and denominated DPB1*9701 by the official World Health Organization Nomenclature Committee.
|Autori interni:||PISTELLO, MAURO|
|Autori:||Lapi S; Curcio M; Fornaciari S; Mariotti ML; Isola P; Bonci F; Pistello M; Scatena F|
|Titolo:||Identification of a novel HLA-DPB1 allele, DPB1*9701, by sequence-based typing|
|Anno del prodotto:||2004|
|Digital Object Identifier (DOI):||10.1111/j.0001-2815.2004.00198.x|
|Appare nelle tipologie:||1.1 Articolo in rivista|