New constituents from Gymnocarpos decander

The phytochemical investigation of Gymnocarpos decander aerial parts extract afforded two new saponins, 3-O-β-D-glucuronopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-O-β-D-apiofuranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl ester (1), 3-O-β-D-glucuronopyranosyl-2β,3β,16α-trihydroxyolean-12-en-28-O-α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl ester (2) and three new flavonol glycosides, isorhamnetin 3-O-2''''-O-acetyl−β-D-xylopyranosyl-(1→6)-[β-D-apiofuranosyl-(1→2)]-β-D-glucopyranoside (3), isorhamnetin 3-O-2'''-O-acetyl−β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside (4), and quercetin 3-O-2'''-O-acetyl−β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside (5), together with three known compounds. Their structures were determined by spectroscopic methods including 1D and 2D NMR analysis and high resolution mass spectrometry. The new isolates were investigated for their potential cytotoxic activity on three cancer cell lines. Compounds 1 and 2 showed a moderate antiproliferative activity.