Several cyclodextrins (CDs) were probed in order to counteract the precipitation of riboflavin-5'-phosphate (or flavin mononucleotide, FMN-P) due to the presence of divalent cations, by exploiting Nuclear Magnetic Resonance (NMR) spectroscopy both for quantitative analyses and stereochemical characterizations. Among CDs, β-cyclodextrin (β-CD) showed the best solubilizing power in virtue of the formation of a 1-2 FMN-P/β-CD complex, the stereochemistry of which was ascertained by ROESY (Rotating-frame Overhauser Enhanced SpectroscopY) measurements.

Cyclodextrins as inhibitors of the precipitation of riboflavin-5'-phosphate due to presence of zinc chloride: A NMR investigation

UCCELLO BARRETTA, GLORIA
Secondo
;
NARDELLI, FRANCESCA;BALZANO, FEDERICA
2017-01-01

Abstract

Several cyclodextrins (CDs) were probed in order to counteract the precipitation of riboflavin-5'-phosphate (or flavin mononucleotide, FMN-P) due to the presence of divalent cations, by exploiting Nuclear Magnetic Resonance (NMR) spectroscopy both for quantitative analyses and stereochemical characterizations. Among CDs, β-cyclodextrin (β-CD) showed the best solubilizing power in virtue of the formation of a 1-2 FMN-P/β-CD complex, the stereochemistry of which was ascertained by ROESY (Rotating-frame Overhauser Enhanced SpectroscopY) measurements.
2017
Aiello, Federica; UCCELLO BARRETTA, Gloria; Falugiani, Niccolò; Nardelli, Francesca; Balzano, Federica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/863274
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