KPC-producing Klebsiella pneumoniae rectal colonization is a risk factor for mortality in patients with diabetic foot infections

Forfori, Francesco; Lipsky, B. A.; Iacopi, Elisabetta; Ripoli, A.; Sbrana, F.; Coppelli, Alessandro; Goretti, C.; Piaggesi, Alberto; Menichetti, Francesco

doi:10.1016/j.cmi.2015.04.010

To evaluate the relationship between carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) gut colonization and mortality in diabetic patients with a foot infection (DFI) we performed a single-centre, retrospective, matched case-control study. In the study period, we identified 21 patients with DFI who had KPC-Kp gut colonization and 21 controls. The 90-day mortality rate was significantly higher in patients with colonized guts (47%) than the controls (4%) (p 0.013). A multivariate analysis demonstrated that gut colonization with KPC-Kp was the only independent predictor of mortality: odds ratio 13.33, 95% CI 1.90-272.80, p 0.024. In patients with DFI, KPC-Kp gut colonization appears to be an important risk factor for mortality.

Autori interni:	FORFORI, FRANCESCO Lipsky, B. A. IACOPI, ELISABETTA Ripoli, A. Sbrana, F. COPPELLI, ALESSANDRO Goretti, C. PIAGGESI, ALBERTO MENICHETTI, FRANCESCO mostra contributor esterni nascondi contributor esterni
Autori:	Forfori, Francesco; Lipsky, B. A.; Iacopi, Elisabetta; Ripoli, A.; Sbrana, F.; Coppelli, Alessandro; Goretti, C.; Piaggesi, Alberto; Menichetti, Francesco
Titolo:	KPC-producing Klebsiella pneumoniae rectal colonization is a risk factor for mortality in patients with diabetic foot infections
Anno del prodotto:	2015
Abstract:	To evaluate the relationship between carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) gut colonization and mortality in diabetic patients with a foot infection (DFI) we performed a single-centre, retrospective, matched case-control study. In the study period, we identified 21 patients with DFI who had KPC-Kp gut colonization and 21 controls. The 90-day mortality rate was significantly higher in patients with colonized guts (47%) than the controls (4%) (p 0.013). A multivariate analysis demonstrated that gut colonization with KPC-Kp was the only independent predictor of mortality: odds ratio 13.33, 95% CI 1.90-272.80, p 0.024. In patients with DFI, KPC-Kp gut colonization appears to be an important risk factor for mortality.
Digital Object Identifier (DOI):	10.1016/j.cmi.2015.04.010
Appare nelle tipologie:	1.1 Articolo in rivista

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